Knock-out and transgenic mouse models of tauopathies
نویسندگان
چکیده
منابع مشابه
Neurodegenerative Tauopathies Human Disease and Transgenic Mouse Models
syndromes are characterized and increasing attention Prominent filamentous tau inclusions are increasingly is focused on the relationship of different FTDP-17 genorecognized as the hallmark neuropathology of a growing types to the heterogeneous phenotypic manifestations family of neurodegenerative diseases collectively known of these hereditary neurodegenerative tauopathies (Hong as tauopathies...
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Tauopathies are a group of neurodegenerative disorders that include Alzheimer's disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) and other related diseases with prominent tau pathology. Research advances in the last several decades have characterized and defined tau neuropathologies of both neuron and glia in these diverse disorders and this has stimulated de...
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Spongiform encephalopathies such as scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle or Creutzfeldt-Jacob disease (CJD) and Gerstmann-Sträussler-Scheinker syndrome (GSS) in humans is caused by a transmissible agent designated prion. The 'protein only' hypothesis proposes that the prion consists partly or entirely of a conformational isoform of the normal host protein PrP(C), d...
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Bacterial Cas9 nuclease induces site-specific DNA breaks using small gRNA as guides. Cas9 has been successfully introduced into Drosophila for genome editing. Here, we improve the versatility of this method by developing a transgenic system that expresses Cas9 in the Drosophila germline. Using this system, we induced inheritable knock-out mutations by injecting only the gRNA into embryos, achie...
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Knockout mice have been informative in the discovery of unexpected biological functions of aquaporins. Knockout mice have confirmed the predicted roles of aquaporins in transepithelial fluid transport, as in the urinary concentrating mechanism and glandular fluid secretion. A less obvious, though predictable role of aquaporins is in tissue swelling under stress, as in the brain in stroke, tumor...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2009
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2007.05.010